Long-term melatonin treatment attenuates body weight gain with aging in female mice

Women usually experience body weight gain with aging, which can put them at risk for many chronic diseases. Previous studies indicated that melatonin treatment attenuates and abdominal fat deposition in several male animals. However, it is unclear whether affects female animals the same way. This study investigated long-term attenuate aging and, if does, what mechanism is. Ten-week-old ICR mice were given melatonin-containing water (100 μg/mL) or only until 43 weeks. Melatonin significantly attenuated 23 weeks (control; 57.2 ± 2.0 g vs melatonin; 44.4 3.1 g), 33 65.4 2.6 52.2 4.2 g) 66.1 3.2 54.4 2.5 without decreasing amount of food intake. Micro-CT analyses showed decreased visceral s.c. fat. These results suggested by inhibiting deposition. Metabolome analysis liver revealed induced a drastic change metabolome downregulation 149 metabolites, including metabolites glucose amino acids. Citrate, serves as source de novo lipogenesis, was one downregulated metabolites. show induces changes metabolism mice.